Jean-Luc Montchamp: One area of significant current interest in Dr. Montchamp’s laboratory is the development of sustainable synthetic methodologies to avoid hazardous phosphorus trichloride (PCl3). The group’s program toward the development of new methodology for the synthesis of phosphinic acids has led to many novel reactions, including the palladium-catalyzed cross-coupling of hypophosphite derivatives with aryl, benzylic, and alkenyl electrophiles, and the room temperature radical addition of hypophosphites to olefins. These reactions are also applied to the synthesis of biologically active compounds, to the preparation of intermediates with industrial value, and to the preparation of P-chiral building blocks. Combining the above research directions into the same program provides valuable advantages. Because phosphorus is ubiquitous in nature, a variety of molecules can be designed to achieve some specific biological effect. To achieve the efficient synthesis of such compounds, new synthetic routes are required, which borrow from independently developed methodologies. Dr. Montchamp’s group employs a combination of organic synthesis, methodology, and chemical biology to pursue their objectives.
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