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Onofrio Annunziata

onofrio annunziata
Professor, Biophysical and Macromolecular Chemistry
MS/BS "Federico II" University of Naples, Italy, 1997 Ph.D. Texas Christian University, 2001 Postdoctoral research Massachusetts Institute of Technology

Research Interests


Annunziata Research Group


  • Macromolecules and Colloids
  • Biophysical Chemistry
  • Physical Chemistry of Solutions

Teaching Interests

  • Physical Chemistry I (Thermodynamics and Electrochemistry)
  • Physical Chemistry II (Quantum Chemistry and Kinetics)
  • Advanced Physical Chemistry (Statistical Thermodynamics, Transport phenomena and Surfaces)
  • Laboratory of Physical Chemistry
  • Biophysical Chemistry
  • Chemical Thermodynamics
  • Physical Chemistry of Colloids
  • Quantitative Chemical Analysis


Onofrio Annunziata received his M.Sc./B.Sc. degree (summa cum laude) in Industrial Chemistry at the Federico II University of Naples, Italy in 1997. His research thesis was on transport properties of surfactants. After graduating, he moved to Fort Worth, TX, where he joined Prof. Albright’s group in the chemistry department at TCU as a research scientist. In 1998, he entered in the Ph.D. program at TCU and, in 2001, graduated with a Ph.D. degree in chemistry, with emphasis in Physical Chemistry. His Ph.D. research dissertation, which was recognized with the Linus Pauling Prize at the 1999 American Crystallographic Association Meeting, focused on understanding protein-salt interactions relevant to protein crystal growth.

In 2001, he moved to Cambridge, MA, and joined Prof. Benedek’s group in the Center of Materials Science & Engineering at MIT where he held a postdoctoral position. At MIT, his work focused on protein aggregation relevant to the cataract disease. In 2004, he joined the Chemistry Department at TCU as an Assistant Professor, and he was then promoted to Associate Professor with Tenure in 2010.

Since 2004 he has taught Physical Chemistry I and II, Advanced Physical Chemistry, Laboratory of Physical Chemistry I and II, Biophysical Chemistry and Quantitative Chemical Analysis. His research activities have focused on

1) how phase transitions and macromolecular crowding can be used to produce new materials based on macromolecules such as proteins and dendrimers, and

2) how concentration gradients of additives can be used to propel target molecules (e.g. proteins, polymers, drug molecules), relevant to controlled-release technologies, self-assembly, adsorption kinetics and molecular motion inside living systems.