We are a group of synthetic chemists, and thus we operate known molecules to create new ones using every available synthetic technique, of both organic and inorganic chemistry. One of our interests is finding new therapeutics, more efficacious and affordable than those currently available. New medicines are prepared using a combination of inorganic and organic syntheses, guided by computational design through docking studies. The performance of the developed drug candidates is tested by our collaborators. These interdisciplinary medicinal chemistry projects combine computational drug design, synthetic inorganic and organic chemistry, purification and characterization by chromatographic and spectroscopic techniques, as well as biological studies, thus providing an opportunity to take an up-close look at the many stages of the drug development process. Our other interests lie in the area of catalysis. Catalysis plays a vital role in a variety of chemical processes that are used to make food, office appliances, household items, transportation, pharmaceuticals, etc.. Still, some industrial processes are economically and environmentally unsustainable. Our goal is design and testing of new transition metal catalysts as well as ligands to improve energy efficiency and reduce emissions for a variety of challenging transformations in the chemical industry. Embracing the abovementioned is our interest in structural chemistry. We use X-ray diffraction analysis to reveal structural details of small inorganic and organic molecules to access a large range of information, including accurate bond lengths and angles, connectivity, conformation, stoichiometry, density, symmetry and the 3D-packing of the atoms.
CHEM 50163: Advanced Inorganic Chemistry
This course provides a comprehensive introduction to diverse topics in modern inorganic chemistry with emphasis on basic understanding and use of its fundamental theories. The course is intended to expand the student’s knowledge base in inorganic chemistry by providing new ways of understanding molecular orbitals, bonding, reactivity, as well as the mathematics of symmetry and how the latter is applied to chemical bonding, spectroscopy, and crystallography. The special focus of the course is transition metal chemistry, and the role these complexes play in the fields of coordination chemistry, organometallic chemistry, bioinorganic chemistry, and materials science. Achievements in recent research and seminar talks presented by visitors during the semester will be discussed.
CHEM 50230/60120: Special Topics in Chemistry: Organometallics
This is a graduate-level survey course covering the principles of organotransition metal chemistry. We explore fundamental principles of organometallic transformations and apply these to contemporary problems in catalysis. A working knowledge of structure, bonding, and reactivity principles (from an inorganic and organic perspective) will be assumed for this course. This also includes familiarity with basic equations of thermodynamics and kinetics, drawing/interpreting molecular structures and orbital diagrams.
CHEM 50230/60120: Special Topics in Chemistry: Introduction to X-Ray Crystallography
This course is focused on single crystal X-ray crystallographic analysis and theory behind it. The first half of the course covers the crystallographic theory, while the second half teaches to use acquired knowledge to solve crystal structures.